|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Agoraphobia
|
|
0.010 |
GeneticVariation |
BEFREE |
We were indeed able to replicate rs5751876 as risk factor for PD, particularly PD with agoraphobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Panic Disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
We were indeed able to replicate rs5751876 as risk factor for PD, particularly PD with agoraphobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Akathisia
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between ADORA1 rs3766566 and psychopathological symptoms (p = 0.006), in particular, with positive psychopathological symptoms (p = 0.010) and general psychopathological symptoms (p = 0.023), between ADORA2A rs2298383 and general psychopathological symptoms (p = 0.046), and between ADORA2A rs5751876 and akathisia (p = 0.015).
|
27195966 |
2016 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Akathisia
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between ADORA1 rs3766566 and psychopathological symptoms (p = 0.006), in particular, with positive psychopathological symptoms (p = 0.010) and general psychopathological symptoms (p = 0.023), between ADORA2A rs2298383 and general psychopathological symptoms (p = 0.046), and between ADORA2A rs5751876 and akathisia (p = 0.015).
|
27195966 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined whether genetic variability in caffeine metabolism [cytochrome P450 1A2 (CYP1A2) -163A-->C] or the main target of caffeine action in the nervous system [adenosine A(2A) receptor (ADORA2A) 1083C-->T] is associated with habitual caffeine consumption.
|
17616786 |
2007 |
|
rs3032740
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551).
|
18759349 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551).
|
18759349 |
2008 |
|
rs5996696
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ADORA2A polymorphisms were inversely associated with PD risk - rs71651683, a 5' variant (adjusted allelic OR = 0.51, 95% CI 0.33-0.80, permutation-adjusted P = 0.015) and rs5996696, a promoter region variant (adjusted OR for AC and CC genotypes compared with the AA wild-type genotype were 0.76 (95% CI 0.57-1.02) and 0.37 (95% CI 0.13-1.01), respectively (permutation-adjusted P for trend = 0.04).
|
21281405 |
2011 |
|
rs71651683
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ADORA2A polymorphisms were inversely associated with PD risk - rs71651683, a 5' variant (adjusted allelic OR = 0.51, 95% CI 0.33-0.80, permutation-adjusted P = 0.015) and rs5996696, a promoter region variant (adjusted OR for AC and CC genotypes compared with the AA wild-type genotype were 0.76 (95% CI 0.57-1.02) and 0.37 (95% CI 0.13-1.01), respectively (permutation-adjusted P for trend = 0.04).
|
21281405 |
2011 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
This study aimed to examine whether functional single nucleotide polymorphisms (SNPs) in 1976T > C (ADORA2A; rs5751876) and -163C > A (CYP1A2; rs762551) influence the effect of caffeine on the postprandial glucose (GLU) response to a carbohydrate meal.
|
31324842 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Severe myopia
|
|
0.010 |
GeneticVariation |
BEFREE |
The reduced frequency of the heterozygote rs5751876 genotype in subjects suggests a possible association of A(2A)R with high myopia in a Chinese population.
|
22740769 |
2011 |
|
rs9624472
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Complicated malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was observed at the rs9624472 locus, where the G allele (approximately 20% frequency) appeared to confer enhanced risk to severe malaria [OR = 1.22 (1.09-1.37); P = 0.001].
|
20386734 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Attention deficit hyperactivity disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Gilles de la Tourette syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with </span>co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
rs9624472
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
The mean of the serum creatinine levels were significantly higher in patients with variant GG (p=0.006) of rs9624472 in ADORA2A gene compared to AA and AG genotypes in complicated Pf malaria cases, with the G allele also showing increased risk for malaria (OR=1.3(1.1-1.6); p=0.017).
|
26066465 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Panic Disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
The combination of MTHFR 1298AA along with ADORA2A rs2298383 CC or CT genotypes occurring in one-third of RA patients showed a higher frequency of general nodules 15/59 (25.4%) as well as developing nodules during MTX treatment 13/59 (22.0%) in comparison with the overall studied group: 24/185 (13.0%) and 19/185 (10.3%), respectively.
|
27846189 |
2017 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
|
28215251 |
2017 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs5751876 T allele was associated with a decreased risk of sleep complaints (Ora = 0.7 [0.3-0.9]) and insomnia (Ora = 0.5 [0.3-0.9]).
|
31817803 |
2019 |
|
rs4822489
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Congestive heart failure
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study suggest that rs4822489 may contribute to the severity of CHF in the northern Chinese.
|
25629231 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-locus analysis showed significant association of 2 SNPs; rs5751876 (OR=3.2(2.0-5.2); p=0.0006) of ADORA2A and rs2230345 (OR=0.3(0.2-0.5); p=0.0006) of GRK5 with malaria.
|
26066465 |
2015 |
|
rs4822489
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, for SNP rs4822489, an association between PDR and T allele homozygosity was observed following covariate adjustment (OR = 0.55; 95% CI: 0.31-0.92; p = 0.04).
|
21088442 |
2011 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
|
20520601 |
2010 |